Usually means: Slang, derogatory term for Down syndrome.
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We found 7 dictionaries that define the word downie:

General (4 matching dictionaries)
  1. Downie: Wordnik
  2. Downie, downie: Wiktionary
  3. Downie: Wikipedia, the Free Encyclopedia
  4. Downie: Rhymezone

Slang (3 matching dictionaries)
  1. downie: Green’s Dictionary of Slang
  2. Downie: Street Terms: Drugs and the Drug Trade
  3. downie: Urban Dictionary

Definitions from Wiktionary (Downie)

noun:  (colloquial, derogatory, offensive) A person with Down's syndrome.
noun:  A surname.
noun:  Alternative spelling of Downie [(colloquial, derogatory, offensive) A person with Down's syndrome.]

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