Usually means: Reduce color intensity; make paler.
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We found 8 dictionaries that define the word desaturate:

General (5 matching dictionaries)
  1. desaturate: Oxford Learner's Dictionaries
  2. Desaturate, desaturate: Wordnik
  3. desaturate: Wiktionary
  4. desaturate: Dictionary.com
  5. desaturate: TheFreeDictionary.com

Medicine (3 matching dictionaries)
  1. desaturate: Merriam-Webster Medical Dictionary
  2. online medical dictionary (No longer online)
  3. desaturate: Medical dictionary

Definitions from Wiktionary (desaturate)

verb:  (transitive) To cause to become less saturated or unsaturated.
verb:  To lessen the saturation of (a colour).
verb:  (chemistry) To convert (a saturated compound) to an unsaturated one.
verb:  (intransitive) To become less saturated or unsaturated.
verb:  (of a colour) To decrease in saturation.
verb:  (medicine) Of the oxygen saturation level in one's hemoglobin: to decrease, to drop.
verb:  (medicine, of a person) To undergo a decrease in the oxygen saturation level in the hemoglobin.

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