Usually means: Reduce or remove masculine traits.
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We found 10 dictionaries that define the word demasculinize:

General (8 matching dictionaries)
  1. demasculinize: Vocabulary.com
  2. demasculinize: Wordnik
  3. demasculinize: Wiktionary
  4. demasculinize: Dictionary.com
  5. demasculinize: Rhymezone
  6. demasculinize: FreeDictionary.org
  7. demasculinize: Mnemonic Dictionary
  8. demasculinize: TheFreeDictionary.com

Medicine (1 matching dictionary)
  1. demasculinize: Merriam-Webster Medical Dictionary

Slang (1 matching dictionary)
  1. demasculinize: Urban Dictionary

(Note: See demasculinizes as well.)

Definitions from Wiktionary (demasculinize)

verb:  To remove the testicles from
verb:  To remove the masculine qualities of.

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