Usually means: Reduction or negative effect applied.
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We found 4 dictionaries that define the word debuff:

General (3 matching dictionaries)
  1. debuff: Wordnik
  2. debuff: Wiktionary
  3. Debuff: Wikipedia, the Free Encyclopedia

Slang (1 matching dictionary)
  1. debuff: Urban Dictionary

Definitions from Wiktionary (debuff)

noun:  (roleplaying games, video games) An effect that makes a game character weaker; a negative status effect.
verb:  (roleplaying games, video games) To make a character or unit weaker.

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