Usually means: Slang term for a cucumber.
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We found 20 dictionaries that define the word cuke:

General (16 matching dictionaries)
  1. cuke: Merriam-Webster
  2. cuke: Oxford Learner's Dictionaries
  3. cuke: American Heritage Dictionary of the English Language
  4. cuke: Collins English Dictionary
  5. cuke: Vocabulary.com
  6. Cuke, cuke: Wordnik
  7. cuke: Wiktionary
  8. cuke: Webster's New World College Dictionary, 4th Ed.
  9. cuke: Infoplease Dictionary
  10. cuke: Dictionary.com
  11. cuke: Cambridge Essential American English Dictionary
  12. Cuke: Wikipedia, the Free Encyclopedia
  13. cuke: Rhymezone
  14. cuke: FreeDictionary.org
  15. cuke: Mnemonic Dictionary
  16. cuke: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. cuke: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. CUKE: Acronym Finder

Slang (2 matching dictionaries)
  1. cuke: Green’s Dictionary of Slang
  2. cuke: Urban Dictionary

(Note: See cukes as well.)

Definitions from Wiktionary (cuke)

noun:  (informal) A cucumber.
noun:  (slang) A cucoloris.

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