Usually means: Thickened skin from repeated friction.
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We found 11 dictionaries that define the word callouses:

General (7 matching dictionaries)
  1. callouses: Merriam-Webster
  2. callouses: Collins English Dictionary
  3. callouses: Vocabulary.com
  4. callouses: Wordnik
  5. callouses: Wiktionary
  6. callouses: Dictionary.com
  7. callouses: TheFreeDictionary.com

Business (1 matching dictionary)
  1. callouses: Legal dictionary

Computing (1 matching dictionary)
  1. callouses: Encyclopedia

Medicine (2 matching dictionaries)
  1. callouses: Medical dictionary
  2. Callouses: Conditions of the Foot and Ankle

(Note: See callous as well.)

Definitions from Wiktionary (callous)

adjective:  (figurative) Emotionally hardened; unfeeling and indifferent to the suffering/feelings of others.
adjective:  (literal) Having calluses, or relating to calluses.
noun:  Alternative form of callus [A hardened area of the skin (especially on the foot or hand) caused by repeated friction, wear or use.]
verb:  Alternative form of callus [(intransitive) To form such hardened tissue.]
▸ Also see callous


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