Usually means: Significant, impactful event or thing.
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We found 8 dictionaries that define the word big one:

General (6 matching dictionaries)
  1. big one, the Big One, the big one: Merriam-Webster
  2. big one: Collins English Dictionary
  3. big one: Wiktionary
  4. big one: Infoplease Dictionary
  5. big one: Dictionary.com
  6. Big One (roller coaster), Big One, The Big One (Daddy Freddy album), The Big One (Dexter), The Big One (NASCAR), The Big One (TV series), The Big One (earthquake), The Big One (film), The Big One (motorsport), The Big One (roller coaster), The Big One (song), The big one: Wikipedia, the Free Encyclopedia

Slang (2 matching dictionaries)
  1. big one: Green’s Dictionary of Slang
  2. big one, the big one: Urban Dictionary

Definitions from Wiktionary (Big One)

noun:  (colloquial) Something important; (with 'the') the most important one, (especially sports) the big game, the big play.
noun:  (US, colloquial) One hundred or one thousand dollars.
noun:  (US, colloquial) A dollar.
noun:  (seismology, colloquial, usually with the) A hypothetical massive earthquake somewhere along the Pacific coast of North America, but especially one projected to cause catastrophic damage to a major city such as Vancouver, Seattle, San Francisco, or Los Angeles.
noun:  (colloquial, by extension) Any other hypothetical event with the potential to be far more devastating than previous events of the same type.

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