Usually means: Large firearm, typically a revolver.
Definitions Related words Mentions
We found 12 dictionaries that define the word big iron:

General (5 matching dictionaries)
  1. Big Iron, big iron: Merriam-Webster
  2. big-iron: Wordnik
  3. big iron: Wiktionary
  4. big iron: Dictionary.com
  5. Big Iron (disambiguation), Big Iron, Big iron (computing), Big iron: Wikipedia, the Free Encyclopedia

Computing (5 matching dictionaries)
  1. big iron: Free On-line Dictionary of Computing
  2. big iron: Netlingo
  3. Webopedia (No longer online)
  4. Technopedia (No longer online)
  5. Big-iron, big iron: Encyclopedia

Medicine (1 matching dictionary)
  1. online medical dictionary (No longer online)

Sports (1 matching dictionary)
  1. 2060 Shadow-Slang (No longer online)

Definitions from Wiktionary (big iron)

noun:  a large pistol
noun:  (computing, slang, humorous, dated) Large, expensive, powerful computers such as mainframes.

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