The term “vicissitudes” has been employed in literature as a versatile metaphor for sudden and often unanticipated changes in fortune, nature, or circumstance. In historical and philosophical texts, authors have used the word to reflect the fluctuating nature of events—be it the transformations experienced by religious traditions ([1], [2]), the unpredictable turns of human fate ([3], [4]), or the inherent shifts in natural cycles ([5], [6]). Classical writers like Cicero and Livy invoked “vicissitudes” to symbolize not merely change but the inevitable interplay between order and chaos in both human endeavors and the natural world ([5], [7]). Similarly, modern and scholarly works, such as those by Bacon and Poe, illustrate its capacity to capture the essence of dramatic life transitions and the erratic nature of existence ([8], [9], [10], [11]). Overall, “vicissitudes” serves as a literary tool that richly conveys the transient and often turbulent state of affairs underlying the human condition.